Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC010
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-24 14:39
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar 250mg 1/2 + 1/4+ 1/2 +1/4 madopar HBS a 250mg 2 uvece

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 9, 'TN': 9, 'TP': 33, 'FP': 21}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 10, 'TP': 33, 'FP': 20}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 23, 'TP': 15, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 19.104
timePerCircleCoV 0.294236
timePerCircleSlope -0.0825339
meanError 1.62348
tremorFreq 6.64062
tremorRelPower 24.5254
tremorGyroAmpMean 0.01709
tremorGyroAmpSlope 0.00315698
tremorGyroAmpCoV 0.35759
tremorCoordAmpMean 0.0383546
tremorCoordAmpSlope 0.00432461
tremorCoordAmpCoV 0.652908
tremorAccAmpMean 0.024599
tremorAccAmpSlope 0.00073557
tremorAccAmpCoV 0.298959
tremorPcRelVar 0.577783
tremorPcX -0.324696
tremorPcY 0.945819

Circle Segment 1

Duration 30.64 s, Accuracy Estimate 3.66 (lower is better)

Circle Segment 2

Duration 27.36 s, Accuracy Estimate 0.9 (lower is better)

Circle Segment 3

Duration 19.2 s, Accuracy Estimate 1.199 (lower is better)

Circle Segment 4

Duration 18.32 s, Accuracy Estimate 1.132 (lower is better)

Circle Segment 5

Duration 19.4 s, Accuracy Estimate 1.38 (lower is better)

Circle Segment 6

Duration 16.88 s, Accuracy Estimate 1.161 (lower is better)

Circle Segment 7

Duration 13.24 s, Accuracy Estimate 1.572 (lower is better)

Circle Segment 8

Duration 15.4 s, Accuracy Estimate 1.398 (lower is better)

Circle Segment 9

Duration 15.76 s, Accuracy Estimate 1.509 (lower is better)

Circle Segment 10

Duration 14.84 s, Accuracy Estimate 2.324 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 45.356
timePerSpiralCoV 0.15585
timePerSpiralSlope -0.0164356
meanError 1.80489
tremorFreq 6.05469
tremorRelPower 26.8414
tremorGyroAmpMean 0.0165189
tremorGyroAmpSlope -0.000511837
tremorGyroAmpCoV 0.408769
tremorCoordAmpMean 0.0484796
tremorCoordAmpSlope 0.00020836
tremorCoordAmpCoV 0.73493
tremorAccAmpMean 0.0347531
tremorAccAmpSlope -0.000168831
tremorAccAmpCoV 0.237798
tremorPcRelVar 0.529588
tremorPcX -0.768634
tremorPcY -0.639688

Spiral Segment 1

Duration 58.8 s, Accuracy Estimate 1.494 (lower is better)

Spiral Segment 2

Duration 44.56 s, Accuracy Estimate 1.484 (lower is better)

Spiral Segment 3

Duration 48.28 s, Accuracy Estimate 1.76 (lower is better)

Spiral Segment 4

Duration 48.0 s, Accuracy Estimate 1.747 (lower is better)

Spiral Segment 5

Duration 37.92 s, Accuracy Estimate 2.383 (lower is better)

Spiral Segment 6

Duration 40.88 s, Accuracy Estimate 2.374 (lower is better)

Spiral Segment 7

Duration 38.24 s, Accuracy Estimate 1.479 (lower is better)

Spiral Segment 8

Duration 36.44 s, Accuracy Estimate 1.667 (lower is better)

Spiral Segment 9

Duration 50.16 s, Accuracy Estimate 1.759 (lower is better)

Spiral Segment 10

Duration 50.28 s, Accuracy Estimate 1.901 (lower is better)

Elel

eDurationMean 0.47304
eDurationStd 0.117796
eDurationStdnorm 0.249019
eDurationMedian 0.450013
eDurationQuartdelta 0.0900025
eDurationQuartdeltanorm 0.2
eDurationKurt 5.54093
eDurationTrenddiff -0.0300008
eDurationTrendratio 0.935484
eWidthMean 6.26329
eWidthStd 2.98511
eWidthStdnorm 0.476603
eWidthMedian 5.733
eWidthQuartdelta 3.3899
eWidthQuartdeltanorm 0.591296
eWidthKurt 3.69943
eWidthTrenddiff 1.872
eWidthTrendratio 1.43243
eHeightMean 9.438
eHeightStd 2.19703
eHeightStdnorm 0.232786
eHeightMedian 9.243
eHeightQuartdelta 3.30548
eHeightQuartdeltanorm 0.357619
eHeightKurt 2.83082
eHeightTrenddiff 2.106
eHeightTrendratio 1.24658
eAspectMean 0.642484
eAspectStd 0.189082
eAspectStdnorm 0.294299
eAspectMedian 0.580851
eAspectQuartdelta 0.274194
eAspectQuartdeltanorm 0.472055
eAspectKurt 2.47528
eAspectTrenddiff 0.103052
eAspectTrendratio 1.19945
eSlantMean 0.0831143
eSlantStd 0.26655
eSlantStdnorm 3.20704
eSlantMedian 0.0291771
eSlantQuartdelta 0.256191
eSlantQuartdeltanorm 8.78055
eSlantKurt 2.92214
eSlantTrenddiff 0.0129868
eRtopMean 0.725305
eRtopStd 0.128633
eRtopStdnorm 0.17735
eRtopMedian 0.740794
eRtopQuartdelta 0.118656
eRtopQuartdeltanorm 0.160174
eRtopKurt 4.2651
eRtopTrenddiff -0.00258968
eRbotMean 0.685625
eRbotStd 0.358001
eRbotStdnorm 0.522152
eRbotMedian 0.661866
eRbotQuartdelta 0.320201
eRbotQuartdeltanorm 0.483786
eRbotKurt 10.4374
eRbotTrenddiff -0.0648865
eRrightMean 0.815074
eRrightStd 0.102425
eRrightStdnorm 0.125663
eRrightMedian 0.829932
eRrightQuartdelta 0.122435
eRrightQuartdeltanorm 0.147524
eRrightKurt 2.20896
eRrightTrenddiff 0.0136213
eRleftMean 0.382585
eRleftStd 0.138199
eRleftStdnorm 0.361224
eRleftMedian 0.3899
eRleftQuartdelta 0.185693
eRleftQuartdeltanorm 0.476257
eRleftKurt 2.69789
eRleftTrenddiff -0.00625216
lDurationMean 0.675368
lDurationStd 0.171862
lDurationStdnorm 0.254472
lDurationMedian 0.670019
lDurationQuartdelta 0.197506
lDurationQuartdeltanorm 0.294776
lDurationKurt 3.702
lDurationTrenddiff -0.170005
lDurationTrendratio 0.768707
lWidthMean 11.7881
lWidthStd 3.49007
lWidthStdnorm 0.296067
lWidthMedian 11.934
lWidthQuartdelta 5.34129
lWidthQuartdeltanorm 0.447569
lWidthKurt 2.1218
lWidthTrenddiff 4.17609
lWidthTrendratio 1.43366
lHeightMean 23.96
lHeightStd 2.69872
lHeightStdnorm 0.112634
lHeightMedian 24.7698
lHeightQuartdelta 4.34448
lHeightQuartdeltanorm 0.175394
lHeightKurt 2.32942
lHeightTrenddiff 2.691
lHeightTrendratio 1.11917
lAspectMean 0.489079
lAspectStd 0.127059
lAspectStdnorm 0.259791
lAspectMedian 0.477011
lAspectQuartdelta 0.201281
lAspectQuartdeltanorm 0.421962
lAspectKurt 2.11925
lAspectTrenddiff 0.156502
lAspectTrendratio 1.36843
lSlantMean 0.203969
lSlantStd 0.128191
lSlantStdnorm 0.628481
lSlantMedian 0.186152
lSlantQuartdelta 0.181416
lSlantQuartdeltanorm 0.974559
lSlantKurt 2.2222
lSlantTrenddiff 0.123633
lRtopMean 0.828054
lRtopStd 0.0716036
lRtopStdnorm 0.0864722
lRtopMedian 0.833333
lRtopQuartdelta 0.0865556
lRtopQuartdeltanorm 0.103867
lRtopKurt 3.39121
lRtopTrenddiff 0.00743323
lRbotMean 0.44604
lRbotStd 0.172657
lRbotStdnorm 0.387089
lRbotMedian 0.384917
lRbotQuartdelta 0.189631
lRbotQuartdeltanorm 0.492653
lRbotKurt 4.63022
lRbotTrenddiff -0.0670869
lRrightMean 0.879513
lRrightStd 0.0543918
lRrightStdnorm 0.0618431
lRrightMedian 0.884028
lRrightQuartdelta 0.0684981
lRrightQuartdeltanorm 0.077484
lRrightKurt 3.27201
lRrightTrenddiff 0.0178675
lRleftMean 0.271084
lRleftStd 0.0902501
lRleftStdnorm 0.332923
lRleftMedian 0.252567
lRleftQuartdelta 0.109804
lRleftQuartdeltanorm 0.434751
lRleftKurt 3.96226
lRleftTrenddiff -0.0363024

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.994932
sumTouchScores 23.8784
meanMovementTime 0.768696
numTouches 24
undershootPercentage 0
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.958494
sumTouchScores 13.4189
meanMovementTime 1.03077
numTouches 14
undershootPercentage 0
overshootPercentage 7.14286

fitts_long data not in signals file.

ZigZag

numZigzags 6
timePerZigzagMean 32.08
timePerZigzagCoV 0.108139
timePerZigzagSlope 0.0436765
meanError 2.07423
tremorFreq 6.64062
tremorRelPower 27.9074
tremorGyroAmpMean 0.0189289
tremorGyroAmpSlope -0.000763868
tremorGyroAmpCoV 0.360226
tremorCoordAmpMean 0.0426533
tremorCoordAmpSlope -0.000974405
tremorCoordAmpCoV 0.361984
tremorAccAmpMean 0.0315133
tremorAccAmpSlope -0.00177379
tremorAccAmpCoV 0.32641
tremorPcRelVar 0.697475
tremorPcX 0.100379
tremorPcY 0.994949

ZigZag Segment 1

Duration 25.48 s, Accuracy Estimate 2.472 (lower is better)

ZigZag Segment 2

Duration 33.6 s, Accuracy Estimate 1.932 (lower is better)

ZigZag Segment 3

Duration 32.28 s, Accuracy Estimate 2.068 (lower is better)

ZigZag Segment 4

Duration 32.68 s, Accuracy Estimate 1.898 (lower is better)

ZigZag Segment 5

Duration 32.68 s, Accuracy Estimate 2.111 (lower is better)

ZigZag Segment 6

Duration 35.76 s, Accuracy Estimate 1.965 (lower is better)

ZigZag Offset

numZigzags 7
timePerZigzagMean 25.0629
timePerZigzagCoV 0.127535
timePerZigzagSlope -0.0571135
zigzagHeightMean 74.1336
zigzagHeightCoV 0.0685735
zigzagHeightSlope 0.0180006
meanError 0.0522814
tremorFreq 6.15234
tremorRelPower 29.738
tremorGyroAmpMean 0.0199959
tremorGyroAmpSlope -0.00031336
tremorGyroAmpCoV 0.361176
tremorCoordAmpMean 0.0514435
tremorCoordAmpSlope 0.00114736
tremorCoordAmpCoV 0.425745
tremorAccAmpMean 0.0763133
tremorAccAmpSlope 0.000278121
tremorAccAmpCoV 0.114434
tremorPcRelVar 0.682562
tremorPcX -0.181143
tremorPcY 0.983457

ZigZag Offset Segment 1

Duration 28.56 s, Accuracy Estimate 0.106 (lower is better)

ZigZag Offset Segment 2

Duration 27.84 s, Accuracy Estimate 0.062 (lower is better)

ZigZag Offset Segment 3

Duration 28.16 s, Accuracy Estimate 0.042 (lower is better)

ZigZag Offset Segment 4

Duration 24.68 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 5

Duration 23.32 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 6

Duration 22.52 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 7

Duration 20.36 s, Accuracy Estimate 0.067 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.18523813390610488}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8713210587438074}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5815761518886456}